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KMID : 0390320030130020174
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Chungbuk Medical Journal
2003 Volume.13 No. 2 p.174 ~ p.183
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Intake of Aflatoxin B1 Increases the Risk of Gastric Cancer in Koreans
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Yoon Jung-Kuk
Kang Jong-Won
Kim Heon
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Abstract
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Puorpose: Aflatoxin B1, which is toxic, mutagenic and carcinogenic has been suspected of contributing to human hepatocellular carcinoma. In recent researches aflatoxin B1 intake have been reported to be related with lung cancer and stomach cancer. However, studies on the associations between dietary intake of aflatoxin B1 and stomach cancer risk are scarce. We have assessed the relationship between dietary intake of aflatoxin B1 and the risk of stomach cancer in Koreans.
Materials and Methods: Two hundred fourteen pathologically-proven stomach cancer patients and 214 age-matched controls were included as the study subjects. Information about food item and dietary intake was collected by direct interview. Level of aflatoxin B1 was determined in 89 Korean food items using competitive ELISA. Intake amount of aflatoxin B1 was estimated by multiplying intake amount of food items and average concentration of aflatoxin B1 in the food items. Detection of p53 and Ki-ras gene mutation using RT-PCR direct sequencing.
Results: The mean aflatoxin B1 intake amount was significantly higher in stomach cancer patients than in controls(OR:1.54 95% CI: 1.05, 2.28). p53 and Ki-ras gene mutations were not significantly related with calorie-adjusted intake amount of aflatoxin B1.
Conclusion: It is suggest that dietary intake of aflatoxin B1 would be a risk factor for stomach cancer in Koreans and low level aflatoxin intake would not induce p53 or Ki-ras mutation in stomach tissue.
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KEYWORD
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Aflatoxin B1, Stomach cancer, p53, Ki-ras
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